PACAP (1-38), Human, Ovine, Rat
Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of ?-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of A?40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the A?-degrading enzyme neprilysin via induction of somatostatin.
| Catalog No. | 5991370 |
| Product Category | Catalog Peptide |
| Sequence | H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 |
| CAS No. | 124123-15-5 |
| Mol. Formula | C203H331N63O53S |
| Mol. Weight | 4534.36 |
| Purity | > 95% |
| MOQ | 1 mg |
| Storage/Stability | -20°C/1 year |
| Shipping | Gel Packs |