Fibrinogen Gamma–chain dodecapeptide

The synthetic dodecapeptide HHLGGAKQAGDV represents the specific platelet receptor recognition site of the human fibrinogen ? chain (residues 400-411). It is a potent inhibitor of the binding of fibrinogen, fibronectin, and von Willebrand factor to thrombin- or ADP-stimulated platelets. The peptide has also been used in studying phosphorylation processes associated with platelet activation.