[Arg15, Asp16, 25, Pro18, 21, 23, Val22, Ile24]-Beta-Amyloid-Protein (15-25)

The undecapeptide RDLPFFPVPID (iA?11) has a similar degree of hydrophobicity as the native amyloid ?-peptide (A?), but with a low propensity to adopt a ?-sheet conformation. It is therefore called anti-?-sheet peptide or ?-sheet inhibitor. iA?11 binds to A?, inhibits A? fibril formation and partially disaggregates preformed fibrils in vitro. This anti-?-sheet peptide may serve as a starting point to design inhibitors of amyloidogenesis in vivo.